关于状细胞相关脏疾病的临床病理学研究:尼日利亚的经验
Muzamil Olamide Hassan1,2, Fatiu Abiola Arogundade1,2, Stephen Adebayo Osasan3
1Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria.
The Nigerian postgraduate medical journal
|February 7, 2024
概括
慢性病 (CKD) 在状细胞病 (SCD) 患者中很常见,经常表现出管管功能障碍和特定的质炎模式. 年龄和疾病严重程度是SCD中CKD的关键预测因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 内部医学 内部医学
背景情况:
- 改善的状细胞疾病 (SCD) 护理增加了成年人的生存率.
- 成年SCD幸存者面临更高的末端器官损伤风险,特别是慢性病 (CKD).
研究的目的:
- 确定SCD患者功能障碍的患病率,模式和预测因素.
- 在SCD中调查与CKD相关的细胞病理变化.
主要方法:
- 评估了105名SCD患者的蛋白尿,估计的淋巴细胞过率 (eGFR) 和管管功能障碍.
- 对22名符合条件的患者进行脏活检,以评估其组织病理学.
- 使用SPSS版本23分析数据.
主要成果:
- 在35.2%的患者中发现了CKD (eGFR <60ml/min/1.73m2和/或蛋白尿).
- (FEK) 和 (FENa) 的高分量分泌表明管管功能障碍.
- 年龄,状细胞计数,血红蛋白和FENa预测了CKD; 组织学发现包括介质血管增殖性淋巴结核炎 (50%).
结论:
- 在SCD中常见的是CKD,标志着管状功能障碍和介血管扩散性球髓炎.
- 在SCD中CKD的关键预测因素是晚年,严重的血管封闭性危机,恶化的贫血和管管功能障碍.
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