和脂肪酸亚组的饮食摄入量与乳腺癌风险之间的关联
Ying Jiang1, Lan-Ting Li1, Si-Han Hou1
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, PR China. zhangcx3@mail.sysu.edu.cn.
Food & function
|February 7, 2024
概括
饮食中的和脂肪酸 (SFAs) 显示与乳腺癌风险有相反的关联. 不同链长的SFAs可能会影响乳腺癌的几率,长奇链的SFAs表现出非线性关系.
科学领域:
- 营养与饮食学 营养与饮食学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 饮食中和脂肪酸对乳腺癌风险的影响仍在争论中,可能因碳链长度而异.
- 了解这些关联对于饮食建议和预防乳腺癌至关重要.
研究的目的:
- 根据链条长度分类的SFA亚组的饮食摄入量与中国的乳腺癌几率之间的关联.
- 探索与更年期状态和BMI的潜在非线性关系和相互作用.
主要方法:
- 一项涉及1661例乳腺癌病例和1674例对照的病例控制研究.
- 通过食物频率问卷和面对面采访来评估饮食摄入量.
- 用于分析的无条件后勤回归和受限制的立方线模型.
主要成果:
- 所有SFA小组都显示出与乳腺癌几率的反向关联.
- 调整后的OR (95%CI) 为中链的0.78 (0.61-0.99),长连锁的0.50 (0.31-0.83),长奇链的0.69 (0.54-0.88) 和非常长链的SFAs的0.67 (0.48-0.95).
- 在长奇链SFAs中观察到非线性M形关联 (P非线性=0.007).
结论:
- 饮食中的SFA,按链长分类,与乳腺癌风险相反相关.
- 研究结果表明,富含SFA的食物在降低乳腺癌风险方面具有潜在的益处,这需要进一步研究.
- 需要进一步的研究,包括前性队列和干预研究,以确认机制.
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