在过渡到年轻成年期期间,注意力缺陷过度活动障碍刺激疗法和处方药滥用
Sean Esteban McCabe1, John E Schulenberg1, Timothy E Wilens1
1Center for the Study of Drugs, Alcohol, Smoking and Health, School of Nursing (S. E. McCabe, Wilens, Schepis, Werner, V. V. McCabe, Veliz), Institute for Social Research (S. E. McCabe, Schulenberg, Veliz), Department of Psychology (Schulenberg), and Department of Psychiatry (Werner, V. V. McCabe), University of Michigan, Ann Arbor; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Harvard University, Boston (Wilens); Department of Psychology, Texas State University, San Marcos (Schepis).
青少年对ADHD的兴奋剂治疗不会增加以后滥用处方药的风险. 然而,滥用处方兴奋剂强烈预测未来的滥用,强调需要监控.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 关于青少年注意力缺陷多动症 (ADHD) 兴奋剂治疗及其与后来的处方药滥用 (PDM) 联系的前性数据有限.
- 了解这种关系对于指导治疗和预防策略至关重要.
研究的目的:
- 调查青少年ADHD兴奋剂治疗与随后PDM风险之间的关联.
- 为了确定在年轻成年期PDM的预测因素.
主要方法:
- 美国12年级学生的纵向研究 (N=11,066) 来自监测未来研究 (2005-2017).
- 自行管理的问卷和每两年进行的随访,直到24岁.
- 多变量分析以评估终身兴奋剂治疗与PDM之间的关联.
主要成果:
- 9.9%的青少年报告为ADHD终身兴奋剂治疗.
- 青少年与没有兴奋剂治疗之间的PDM风险没有显著差异.
- 青少年滥用处方兴奋剂显示明显更高的后期PDM的几率.
结论:
- 青少年对ADHD的兴奋剂治疗与晚期PDM的风险增加无关.
- 滥用处方兴奋剂是未来PDM的强有力的预测因素.
- 建议监测青少年是否滥用处方兴奋剂,以减轻未来的风险.
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