在儿童中出现SARS-CoV-2的后急性后果
Suchitra Rao1, Rachel S Gross2,3, Sindhu Mohandas4,5
1Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
Pediatrics
|February 7, 2024
概括
后急性COVID-19 (PASC) 或长期COVID的后续影响着持久或新出现症状的儿童. 关于其患病率,机制和儿童群体的长期健康影响的研究正在出现.
科学领域:
- 儿童传染病 儿童传染病
- 纵向健康研究 纵向健康研究
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19的流行,全球健康面临着重大挑战.
- 虽然大多数成年人从急性感染中恢复过来,但有一部分人经历了长时间的症状,称为SARS-CoV-2感染 (PASC) 或长期COVID的后急性继发症.
- 新出现的数据表明,儿童也可能经历PASC,呈现出多样化,有时是新的条件.
研究的目的:
- 提供关于儿童PASC的当前知识的全面概述.
- 总结PASC在儿童群体中的流行,流行病学,风险因素,临床特征和潜在机制.
- 根据美国国立卫生研究院 (NIH) 的定义,为儿科PASC提出一个概念框架,并强调正在进行的NIH资助的研究倡议.
主要方法:
- 这是一个叙事综述,综合了有关儿科PASC的现有文献.
- 它结合了电子健康记录队伍的发现,以进行快速,大规模的评估.
- 纵向前观测队伍被用来研究疾病负担和轨迹.
主要成果:
- 儿童的PASC可以表现为持续的症状 (例如,疲劳,咳) 或新出现的疾病 (例如,POTS,MIS-C).
- 风险因素,流行病学数据和临床特征仍在被阐明.
- 目前正在进行的研究旨在描述自然史和长期健康影响.
结论:
- 了解儿童的PASC对于解决COVID-19大流行病的长期健康后果至关重要.
- 由NIH资助的倡议对于描述儿科PASC和为未来的治疗和预防策略提供信息至关重要.
- 需要进一步的研究,才能充分了解PASC在儿童和年轻人的病理生物学和临床结果.
相关概念视频
01:17Pulmonary Cycle: Exhalation
1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
01:29Pneumonia II: Pathophysiology
274
The pathophysiology of pneumonia involves the following steps:
274
01:30Pneumonia I: Introduction
239
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
239
01:30Pneumonia III: Complications and Assessment
225
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
225
01:30Acute Pharyngitis
678
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
678
01:21Acute Respiratory Failure-II
236
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
236