相关实验视频
Updated: Jul 4, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.6K
转移性颗粒细胞瘤:一种罕见的实体
Dimosthenis Zylis1, Stefania Kokkali1,2, Michail Sofopoulos3
1First Medical Oncology Clinic, Saint-Savvas Cancer Hospital, Athens, Greece.
International journal of surgical pathology
|February 7, 2024
概括
一种罕见的非典型颗粒细胞瘤在30年后表现出侵略性行为,局部复发并转移到肺部. 尽管接受了治疗,但该患者的结局是致命的,这凸显了对这种罕见的软组织瘤需要更好的管理策略的需要.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 软组织新生体.
背景情况:
- 颗粒细胞瘤 (GCTs) 是一种罕见的软组织瘤,其血统不确定,通常重复施万细胞表型.
- 在组织学上,GCT被分类为良性,非典型或恶性,大多数病例表现出惰的行为.
- 由于GCTs的稀有性,生物学,临床过程和最佳管理仍然不太了解.
研究的目的:
- 描述一种非典型的颗粒细胞瘤的临床过程,其长期的惰期随后有侵略性的复发和转移.
- 为了突出管理复发性和转移性GCT的挑战,考虑到数据的稀缺性.
主要方法:
- 病例报告详细介绍了一名患有皮肤非典型颗粒细胞瘤的患者.
- 30年来瘤的演变描述,包括手术切除,复发和转移性传播.
- 基于转移性疾病软组织肉瘤指南的全身疗法.
主要成果:
- 一种非典型的颗粒细胞瘤在30年惰期后局部复发并转移到肺部.
- 由软组织肉瘤协议指导的全身疗法导致疾病进展.
- 患者经历了致命的结局,强调了先进的GCT的攻击性潜力.
结论:
- 复发性和/或转移性颗粒细胞瘤是一种罕见的,可能危及生命的疾病,治疗反应不明.
- 非典型和恶性GCT表现出与良性GCT不同的攻击性行为,这需要临床警和与软组织肉瘤的比较.
- 需要进一步的研究来探索辅助化疗和放射治疗在预防复发中的作用.
更多相关视频
09:33Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
1.1K
08:57Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
1.9K
相关概念视频
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
01:30Classification of Leukocytes
1.9K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
1.9K