冠状动脉血管功能障碍或没有冠状动脉血管功能障碍的ANOCA患者,目前有有限的心电图改造
Diantha J M Schipaanboord1, Tijn P J Jansen2, Caïa Crooijmans2
1Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
International journal of cardiology. Heart & vasculature
|February 7, 2024
概括
冠状动脉动脉功能障碍 (CVDys) 患者在术前心电图上表现出略有延长的QTc间隔. 这一发现表明,CVDys患者的心脏重塑最少,有助于诊断和管理.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 冠状动脉动脉功能障碍 (CVDys),包括冠状动脉 (CVS) 和/或冠状动脉微血管功能障碍 (CMD),在非阻塞性冠状动脉疾病 (ANOCA) 的心痛中很常见.
- 侵入性冠状动脉功能测试 (CFT) 越来越多地用于CVDys诊断和病理生理学研究.
- 了解ANOCA心血管疾病患者的电生理学特征对于改善诊断策略至关重要.
研究的目的:
- 研究被诊断患有心血管疾病的ANOCA患者的电生理学特征.
- 为了比较心电图 (ECG) 发现,有和没有心血管疾病的患者.
- 在ANOCA患者中识别与心血管疾病相关的潜在ECG标记物.
主要方法:
- 来自NL-CFT注册表的程序前12ECG的回顾性分析.
- 包括ANOCA患者被分为:CVS (n=35),CMD (n=24),CVS/CMD (n=26) 和没有心血管疾病 (CFT-, n=23).
- 患者组之间的心轴,导电时间和QTc间隔 (QTcB,QTcF) 的比较.
主要成果:
- 心脏轴,心率,PQ间隔和QRS持续时间在所有组都相似.
- 在CMD和CVS/CMD患者中,与没有CVDys的患者相比,观察到修正的QT间隔 (QTc) 的统计学意义上的延长,尽管很小 (p<0.05).
- 患有CVS的患者也表现出延长QTc间隔的趋势,尽管不具有统计学意义 (p>0.05).
结论:
- 在ANOCA中,患有CVDys的患者的手术前心电图显示,与没有CVDys的患者相比,QTc间隔略长.
- 这一发现表明,在患有心血管疾病的患者中,心脏重塑有限.
- 延长的QTc间隔可以作为潜在的,在心血管疾病的诊断工作中的非侵入性指标.
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