结核病重叠综合征:毛囊镜检查,实验室和临床表现以及跟踪与结核病患者相比
Saeedeh Shenavandeh1, Zahra Azariyon1, Mohammad Ali Nazarinia1
1Division of Rheumatology, Department of Internal Medicine, Shiraz University of Medical Science, Iran.
Reumatologia
|February 7, 2024
概括
与有限的SSc (LcSSc) 相比,多样性硬化重叠综合征 (SSc-OS) 患者的器官参与较少,毛细血管损伤进展较慢. 随访显示,在SSc-OS患者中没有新的数字.
科学领域:
- 类风湿病学 类风湿病学
- 系统性连接组织疾病 系统性连接组织疾病
- 硬化性皮质是一种硬化性皮质.
背景情况:
- 叠加综合征 (OS) 涉及符合两个或两个以上连接组织疾病 (CTD) 标准的患者.
- 硬化硬化症OS (SSc-OS) 是一种涉及硬化硬化症的特殊形式的OS.
- 将SSc-OS与有限的SSc (LcSSc) 进行比较有助于理解疾病的进展和表现.
研究的目的:
- 评估SSc-OS患者的临床,实验室和毛细管学特征.
- 为了比较SSc-OS与LcSSc在10年的进展情况.
- 为了识别器官参与和指甲折毛细管透视模式的差异.
主要方法:
- 一项长达10年的横截面研究包括135名成年患者 (70名SSc-OS,65名LcSSc).
- 收集的数据包括临床,实验室,HRCT,心声学和指甲折叠毛细管透视.
- 患者在基线和随访期间进行了比较.
主要成果:
- 在SSc-OS患者中,肌肉骨参与度较高,毛细血管检查模式不特异 (p=0.035,p=0.001).
- 在SSc-OS (p=0.000) 中,数字和硬质皮质毛细镜模式较低 (p=0.000).
- 在随访期间,SSc-OS显示肺部参与的进展较低 (p=0.002) 和毛细血管损伤 (p=0.000),没有新的数字.
结论:
- SSc-OS,特别是SSc-SS子组,表现出比LcSSc更少的主要器官参与.
- SSc-OS表现出皮肤得分的进展较慢,肺部参与和毛细血管损伤.
- 这些发现表明SSc-OS在特定并发症方面可能具有较轻的疾病过程.
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