2型糖尿病与基于MRI脂肪分数映射的身体组成之间的关联
Qi An1, Qin-He Zhang1, Yue Wang1
1Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in public health
|February 7, 2024
概括
2型糖尿病 (T2DM) 与内脏脂肪组织 (VAT) 和胰腺脂肪分数 (PFF) 的增加有关. PFF是T2DM的强有力的独立风险因素和诊断生物标志物,突出其在疾病病理生理学中的作用.
科学领域:
- 医疗成像医学成像
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 是一个具有复杂病因的全球性健康问题.
- 身体组成,特别是脂肪组织的分布和含量,在代谢健康中起着重要作用.
- 磁共振 (MR) 脂肪分数 (FF) 映射提供了对组织组成的定量见解.
研究的目的:
- 通过MR脂肪分数 (FF) 映射来研究T2DM与身体组成之间的关联.
- 为了确定与T2DM相关的特定身体脂肪储存和肌肉特征.
- 在区分T2DM患者中评估身体组成参数的诊断性能.
主要方法:
- 在341名受试者 (68名T2DM,273名非T2DM) 进行了带有FF映射的腹部MRI.
- 对内脏脂肪组织 (VAT) 面积和FF,皮下脂肪组织 (SAT) 面积和FF,腹肌 (AM) 面积和FF的量化.
- 使用3D半自动细分测量肝脂肪分数 (HFF) 和胰腺脂肪分数 (PFF).
主要成果:
- 与非T2DM对照组相比,T2DM患者的增值税面积,增值税FF,HFF和PFF显著增加 (P <0.05).
- 两组之间在SAT或AM特征上没有发现显著差异 (P > 0.05).
- 增值税区域和PFF成为T2DM的独立风险因素,与增值税区域 (AUC = 0.685) 相比,PFF显示出更高的诊断性能 (AUC = 0.787).
结论:
- 在T2DM和增值税,HFF和PFF之间存在显著的关联.
- 增值税领域和PFF是T2DM的独立风险因素.
- 作为T2DM预防和治疗的成像生物标志物,PFF显示出高的诊断潜力.
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