休时间的久坐行为与椎脊椎病,腹筋痛,椎间盘疾病和腰部疼痛的因果关系:孟德尔的随机化研究
Youjia Qiu1, Xingzhou Wei2, Yuchen Tao2
1Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Frontiers in public health
|February 7, 2024
概括
观看电视 (电视) 与 sciatica,椎间盘退化 (IVDD) 和腰部疼痛 (LBP) 的风险增加有关. 这些关联可能由体重指数 (BMI),吸烟和2型糖尿病 (T2DM) 介导.
科学领域:
- 流行病学 流行病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 久坐不动的行为越来越被认为是肌肉骨疾病的潜在危险因素.
- 休时间的久坐行为 (LSB),包括看电视,使用电脑和开车,需要对其在特定脊柱状况中的因果作用进行调查.
研究的目的:
- 调查不同类型的LSB之间的潜在因果关联和 sciatica,椎间盘退化 (IVDD),腰部疼痛 (LBP) 和椎脊椎病 (CS) 的发生率.
- 探索潜在的调解因素,如身体质量指数 (BMI),吸烟开始,和2型糖尿病 (T2DM),在LSB和这些条件之间的关系.
主要方法:
- 利用孟德尔随机化 (MR) 分析与全基因组关联研究 (GWAS) 的数据来评估因果关系.
- 采用逆变量加权 (IVW),MR-Egger和加权中位数方法进行初级分析,使用MR-PRESSO和MR-Egger拦截进行灵敏度分析.
- 进行多变量MR (MVMR) 来确定特定LSB和两步MR的独立影响,以确定潜在的调解者.
主要成果:
- 电视观看显示了显著的积极因果关系与CS,IVDD,LBP和 sciatica风险增加.
- 电脑使用与IVDD,LBP和 sciatica风险降低有关.
- MVMR证实了电视观看对IVDD,LBP和 sciatica的独立因果作用,BMI,吸烟开始和T2DM被确定为潜在的调解者.
结论:
- 这项研究提供了强有力的证据,证明电视观看与 sciatica,IVDD和LBP风险之间的积极因果关系.
- 确定了BMI,吸烟开始和T2DM的调解作用,突出了减轻这些风险的潜在干预目标.
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