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肠道微生物群及其对瘤微环境相互作用的治疗影响

Pengya Feng^1,2,3, Xia Xue^1,3, Ihtisham Bukhari^1,3

¹Key Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in microbiology

|February 7, 2024

概括

肠道微生物组显著影响瘤微环境 (TME) 和癌症进展. 了解这种肠道微生物群-TME相互作用为有效的癌症免疫疗法和个性化医学提供了新的途径.

科学领域:

在瘤学瘤学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

癌症的发展涉及瘤微环境 (TME) 内的复杂相互作用.
包括肠道微生物组在内的TME在瘤开始,进展,转移和治疗反应中发挥着关键作用.
目前针对TME的治疗方法显示临床疗效不足.

研究的目的:

审查肠道微生物群在人类癌症中的作用.
探索肠道微生物群和TME之间的相互作用.
突出肠道微生物群在癌症治疗中的潜在应用.

主要方法:

文献综述总结了有关肠道微生物群和癌症的现有研究.
分析肠道微生物群与瘤微环境之间的相互作用.
讨论新的治疗策略.

主要成果:

肠道微生物组是TME的重要组成部分,对癌症免疫治疗至关重要.
链接肠道微生物群和TME的框架可以增强癌症治疗策略.
便微生物群移植,饮食变化和合成生物学都是以肠道微生物群为基础的有希望的方法.

结论:

了解肠道微生物群-TME轴对于开发有效的癌症治疗至关重要.
本综述为针对癌症护理中的肠道微生物群的个性化医疗方法提供了基础.

关键词:

癌症治疗疗法癌症治疗我们的肠道微生物群.微生物群瘤微环境合成生物学合成生物学治疗目标是治疗的目标.

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