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与HPV相关的口腔状细胞癌的诊断延迟

Patrick O McGarey¹, Osama Hamdi¹, Lane Donaldson¹

¹Division of Head and Neck Oncologic and Microvascular Surgery, Department of Otolaryngology, Head and Neck Surgery, University of Virginia, Charlottesville, VA, United States.

International archives of otorhinolaryngology

|February 7, 2024

概括

人类乳头瘤病毒阳性口喉状状细胞癌 (HPV+OPSCC) 往往呈现独特,导致诊断延迟. 为医疗保健提供者提供有针对性的教育对于改善HPV+OPSCC的及时诊断和治疗至关重要.

科学领域:

在瘤学瘤学.
耳鼻喉科耳鼻喉科耳鼻喉科
病理学病理学病理学

背景情况:

人类乳头瘤病毒相关的口腔状细胞癌 (HPV+ OPSCC) 的发病率正在上升.
由于其独特的临床特征,HPV+ OPSCC存在独特的诊断挑战.

研究的目的:

调查HPV+OPSCC独特的临床表现如何影响诊断延迟.
为了比较HPV+ OPSCC与HPV-阴性OPSCC的诊断途径.

主要方法:

在2002年至2014年期间接受治疗的284名OPSCC患者的回顾性审查.
通过包括多次非诊断活检,重复抗生素疗程或手术期间误诊在内的标准来定义诊断延迟.
分析了与p16状态相关的症状,临床特征和诊断时间表.

主要成果:

与p16-瘤相比,HPV+OPSCC (p16+) 更频繁地呈现为部质量 (85.1%) 和较少的耳鼻瘤 (24.6%).
患有HPV+OPSCC的患者更有可能经历诊断延迟 (77.7%vs62.8%).
身体检查时p16+瘤的检测率较低 (19.0%对6.7%),并且与非诊断性小针吸入 (FNA) 节点质量 (11.8%对3.4%) 更为相关.

结论:

HPV+ OPSCC 的独特临床表现有助于增加诊断延迟.
早期和准确的HPV+OPSCC诊断受到其微妙或非典型症状的阻碍.
在HPV+OPSCC的独特特征上教育医疗保健提供者可能会缩短诊断和治疗的时间.

关键词:

这是一个HPVHPVHPV.头部和部癌症头部和部癌症人类乳头瘤病毒病毒病毒口腔喉皮状细胞癌的发生.

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