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在db/db小鼠中,Artemether通过线粒体pyruvate氧化来调节肝脏的糖原和脂质利用

Wenci Weng¹, Lingling Shen², Xuewen Yu³

¹Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine No. 1 Fuhua Road, Futian District, Shenzhen 518033, Guangdong, China.

American journal of translational research

|February 7, 2024

概括

在2型糖尿病中,Artemether通过增强线粒体的pyruvate代谢和调节糖原和脂质利用来改善肝功能. 这项研究阐明了它在小鼠中的抗糖尿病机制.

科学领域:

代谢障碍代谢障碍代谢障碍
药理学药理学是指药理学的学科.
生物化学生化学

背景情况:

2型糖尿病 (T2D) 是一个全球性的健康问题,影响多个器官,特别是肝脏.
从甲素中衍生出来的甲乙烯,显示出抗糖尿病的潜力,但它对葡萄糖代谢的影响需要阐明.
肝 mitochondrial pyruvate 代谢对于 T2D 中的葡萄糖平衡至关重要.

研究的目的:

在T2D中研究甲基对肝脏线粒体酸盐代谢的影响.
探索阿尔特梅抗糖尿病作用的潜在机制.
在T2D小鼠模型中评估阿尔特梅瑟对葡萄糖和脂质代谢的影响.

主要方法:

2型糖尿病 (db/db) 的小鼠和瘦肉野生类型的对照小鼠在12周内接受了阿尔特的治疗.
评估的呼吸交换比率 (RER),氧化还原状态,血清/肝脏脂质,肝脏糖原,以及胰岛素/IGF-1信号传递.
分析了肝脏线粒体的pyruvate氧化,脂肪酸和糖原代谢途径.

主要成果:

在T2D小鼠中,阿尔特美增加了RER,并增强了肝脏线粒体的pyruvate代谢.
减少脂质过氧化,改善肝脏氧化还原状态,减弱肝脏糖原积累.
调节胰岛素/IGF-1信号传递,血清胰岛素水平,以及肝脏的糖原/脂质代谢.

结论:

在T2D小鼠中,Artemether有效调节肝脏糖原和脂质利用率.
抗糖尿病机制包括在肝脏中调节线粒体的酸盐氧化.
阿尔特梅瑟证明了通过肝脏代谢调节来管理T2D的治疗潜力.

关键词:

阿尔特梅瑟和阿尔特梅瑟是一个人.糖原糖原是一种糖原.脂质脂质是什么意思脂质脂质是什么意思肝脏肝脏肝脏肝脏肝脏肝脏皮鲁酸是一种酸盐.

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