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益生菌补充剂可以纠正口服益生菌缺乏,以长期缓解过敏
1AllerPops Corp 1650 Trinity Dr. #103, Los Alamos, NM 87544, USA.
American journal of translational research
|February 7, 2024
概括
通过增加有益的口腔细菌,AllerPops的益生菌补充剂有效地缓解了过敏症状. 这项研究表明,口服益生菌的缺乏可能导致过敏性鼻炎,影响免疫系统调节.
科学领域:
- 免疫学和微生物学
- 胃肠道学和营养学
背景情况:
- 过敏性鼻炎的患病率急剧增加,促使人们对传统卫生假设之外的潜在原因进行研究.
- 具体的口腔卫生假设提出口腔益生菌缺乏症和过敏性鼻炎之间的联系.
研究的目的:
- 为了验证口服益生菌缺乏导致过敏性鼻炎的理论.
- 评估AllerPops在缓解鼻腔过敏症状和调节口腔微生物群方面的疗效.
主要方法:
- 这是一项为期21天,随机,双盲,受控的II期临床试验,涉及72名过敏成年志愿者.
- 参与者接受了AllerPops,研究小组在服用前练习了特定的口腔卫生.
- 口腔微生物组分析使用了16S核糖体RNA基因片序列测序.
主要成果:
- AllerPops显著减少了过敏症状 (P = 0.002).
- 补充剂调节了有益的口腔细菌 (Fusobacteria,Butyrivibrio,Peptostreptococcus),它们产生短链脂肪酸 (SCFA).
- 临床改善与这些SCFA产生益生菌的丰度增加相关.
结论:
- 口服益生菌缺乏被确定为过敏性鼻炎的潜在根本原因.
- AllerPops在持续的过敏缓解和恢复有益的口腔细菌方面表现出有效性.
- 研究结果表明,需要重新定义口腔卫生实践,以保护口腔益生菌和预防免疫相关疾病.
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