甘酸A通过降低细胞内JAK2-STAT3信号通路的调节来减弱肝功能障碍,在诱导的中毒中
Chenggen Xiao1, Guoqing Huang1, Xiaoxia Cao2
1Department of Emergency Medicine, Xiangya Hospital, Central South University Changsha 410000, Hunan, China.
American journal of translational research
|February 7, 2024
概括
光有效治疗中毒,将死亡率降至0%并改善肝功能. 这种天然化合物显示出作为对α-amanita中毒的重要解药的希望.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
背景情况:
- 中毒,特别是来自α-amanita的中毒,对公众健康构成了重大挑战.
- 目前,对于严重的中毒,还没有特定的解药.
- 目前,Ganoderma lucidum正在研究其潜在的治疗效果.
研究的目的:
- 为了评估Ganoderma lucidum在治疗急性中毒中的疗效.
- 探索根底的机制 甘 lucidum的作用对抗α-amanita毒性.
主要方法:
- 在20年间对556例中毒病例进行了回顾性分析.
- 在治疗Ganoderma lucidum之前和之后评估死亡率和肝功能 (ALT,AST,BA,STB).
- 在体内 (小鼠) 和体外实验中阐明作用机制,包括JAK2-STAT3通路的抑制.
主要成果:
- 2002年之前:35%的死亡率在55例病例 (372人).
- 2002年以后 (用Ganoderma lucidum):184名患者的死亡率为0%,肝功能在10天内显著改善.
- 光治疗降低了发病率 (OR=0.58),改善了肝酶,缩短了住院时间. 甘酸A增强了小鼠的生存率,并抑制了JAK2-STAT3通路.
结论:
- 甘白 (Ganoderma lucidum) 在治疗α-amanita中毒方面表现出高效.
- 这项研究支持推广Ganoderma lucidum作为治疗中毒的方法.
- 甘酸A对JAK2-STAT3通路的抑制是其治疗效果的潜在机制.
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