加厚的围脂肪预测免疫球蛋白A脏病患者的脏状况不佳:基于人口的回顾性队列研究
Hongtu Hu1,2, Zongwei Zhang1,2, Zikang Liu1,2
1Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China.
Kidney diseases (Basel, Switzerland)
|February 7, 2024
概括
在IgA脏病 (IgAN) 患者中,增加周周脂肪厚 (PFT) 与病进展的风险更高有关. 这一发现表明PFT可能作为IGAN的有价值的预后标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 医疗成像医学成像
- 脏病理学 脏病理学
背景情况:
- 围脂肪 (PF) 影响功能,但其在IgA病 (IgAN) 进展中的作用尚不清楚.
- IgAN是一种常见的淋巴细胞疾病,临床结果各不相同.
研究的目的:
- 调查周围脂肪厚度 (PFT) 与IGAN进展之间的关联.
- 为了确定PFT是否可以预测Igan患者的结局.
主要方法:
- 招募了473名经过活检证明的Igan患者和473名健康对照.
- 在脏活检中使用彩色多普勒超声波测量PFT.
- 使用考克斯回归和卡普兰-梅尔分析分析了PFT和综合终点 (双倍肌素,ESRD) 之间的关系.
主要成果:
- 与对照组相比,Igan患者的PFT显著增加.
- 较高的PFT与综合终点的风险增加密切相关 (p < 0.001).
- 75名患者 (15.9%) 达到终点,高PFT组为26.5%,低PFT组为5.4%.
结论:
- 在IgAN中,周围脂肪厚度与进展有关.
- 在IgAN患者中,PFT可作为预测性预后不良的标志物.
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