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芳香氨基酸代谢物改变干扰素信号传递和流感病原发生

Gautam Anand¹, Colin Clark-Dinovo¹, Alexandra M Perry¹

¹Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, United States.

Frontiers in molecular biosciences

|February 7, 2024

概括

来自芳香氨基酸的肠道微生物代谢物影响宿主免疫力. 发现某些代谢物,特别是来自氨酸和氨酸的代谢物,可以增强干扰素信号传递,并改善小鼠在流感感染期间的结果.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
代谢学代谢学代谢学

背景情况:

肠道微生物代谢物显著影响宿主生理学.
芳香氨基酸 (三聚,氨酸,氨酸) 被微生物群广泛代谢.
之前的研究表明,氨酸代谢物增强了I型干扰素 (IFN) 信号传递和流感保护.

研究的目的:

选芳香氨基酸代谢物对它们对IFN信号传输的影响.
调查这些代谢物对流感感染和病毒载荷的影响.
阐明代谢物介导免疫调节的潜在机制.

主要方法:

在人类肺上皮细胞和单细胞中选17种芳香氨基酸代谢物.
仅用代谢物治疗,使用IFN-β,流感和脂多糖 (LPS).
RNA测序以识别基因表达变化和通过基因沉默和TGF-β抑制进行验证.

主要成果:

类代谢物降低了IFN信号传递,而氨酸和氨酸代谢物则表现出不同的,取决于细胞类型的效应.
聚合的代谢物减少了流感恢复,病毒载荷和IFN信号传输,而托代谢物显示出主导作用.
代谢物诱导的IFN信号抑制被TGF-β抑制逆转,这表明有机械联系.

结论:

肠道微生物代谢物可以调节宿主IFN信号,其影响因代谢物和细胞类型而异.
微生物代谢物可以影响流感的发病,可能通过TGF-β信号通路.
在感染之前,这些代谢物的鼻内注射改善了小鼠流感模型中的结果.

关键词:

这是一种炎症炎症炎症炎症.流感流感流感流感流感干扰子干扰子干扰子微生物代谢物的代谢物.我们的微生物群.

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