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开发和验证Siewert II食管胃结腺癌的名图:一个追溯分析
Tao Jin1,2, Ze-Dong Li1,2, Ze-Hua Chen1,2
1Department of General Surgery & Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Therapeutic advances in medical oncology
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概括
一个新的预测模型准确地预测了食道胃结 (AEG) 的Siewert II腺癌的存活率. 与AEG患者目前的AJCC TNM分期系统相比,该模型提供了更好的预后见解.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 胃食道结节 (AEG) 的腺癌,特别是西沃特II型,提出了复杂的分类挑战.
- 目前美国癌症联合委员会 (AJCC) 的第7和第8次瘤结节转移 (TNM) 阶段测定系统对西韦特II AEG患者的预后预测不充分.
研究的目的:
- 确定影响Siewert II AEG生存和预后的关键因素.
- 为 Siewert II AEG.开发和验证一种新的,更准确的预后预测模型.
主要方法:
- 从SEER数据库 (培训组) 和单一的第三级医疗中心 (外部验证组) 的Siewert II AEG患者的回顾性分析.
- 使用通过单变量和多变量考克斯回归分析识别的显著变量构建名图.
- 使用一致性指数 (C指数),校准图表和决策曲线分析 (DCA) 评估名ogram性能.
主要成果:
- 纳米图包括年龄,瘤等级,瘤大小和TNM阶段 (T,N,M).
- 该名录在SEER培训组中获得0.683的C指数,在外部验证组中获得0.690的C指数.
- 校准图表显示预测和观察结果之间的良好一致性,DCA表明了临床效用.
结论:
- 开发的诺米图表在预测Siewert II AEG.的预后方面表现出显著的准确性.
- 与现有的分期系统相比,这种新的预测模型提供了一个更可靠的工具来评估患者的结果.
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