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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
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基于微流体的芯片上的人类前列腺癌.

Linan Jiang1, Hunain Khawaja2, Shekha Tahsin2

  • 1Department of Aerospace and Mechanical Engineering, Tucson, AZ, United States.

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一个新的前列腺癌-芯片 (PCoC) 模型重现了人类前列腺瘤和肌相互作用. 这种微流体系统揭示了瘤细胞如何诱导癌症相关纤维细胞 (CAF) 并促进侵袭,帮助前列腺癌研究.

关键词:
与癌症相关的纤维细胞 (CAFs).微流体学 在微流体学方面器官在芯片上的器官前列腺癌是前列腺癌.前列腺瘤的入侵前列腺瘤的入侵.流体纤维细胞.瘤微环境是一个微环境.

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科学领域:

  • 生物医学工程 生物医学工程
  • 癌症生物学 癌症生物学
  • 微流体学 微流体学

背景情况:

  • 目前的前列腺癌模型不充分代表人类生理学,阻碍了治疗耐药性和骨转移的治疗开发.
  • 现有的体外模型缺乏复杂性,而体内动物模型与人类存在生理和遗传差异.

研究的目的:

  • 开发和验证第一个体外微流体人类前列腺癌芯片 (PCoC) 模型.
  • 调查动态的瘤-肌瘤相互作用,包括癌症相关纤维细胞 (CAF) 转化和瘤细胞入侵.

主要方法:

  • 在具有多孔膜的微流体装置中共同培养人类前列腺癌和 stromal 纤维细胞.
  • 使用免疫光显微镜分析细胞-细胞信号,CAF生物标记物表达 (αSMA,COL1A1),雄激素受体 (AR) 下调和瘤入侵.
  • 模拟溶解物度梯度以与CAF转换水平相关联.

主要成果:

  • 前列腺癌细胞诱导CAF转化在流体纤维细胞中,转化水平沿中流方向增加.
  • 瘤细胞降低了 stromal AR 表达的调节,与正常前列腺平衡不同.
  • PCoC模型证明了瘤细胞和CAF入侵邻近的隔间,突出显示了肌层在促进转移中的作用.

结论:

  • 开发的PCoC模型有效地回顾了空间时空瘤-肌瘤相互作用和与人前列腺癌相关的多细胞反应.
  • 这种模型是剖析前列腺癌机制和探索新治疗策略的宝贵工具.