相关实验视频

Updated: Jul 4, 2025

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Published on: December 9, 2018

胃食道逆流疾病和中风之间的关联:双向的门德尔随机化研究

Decheng Meng¹, Xin Zhang¹, Wenfei Yu¹

¹First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Frontiers in neurology

|February 7, 2024

概括

胃食道逆流性疾病 (GERD) 因果性地增加了中风风险,包括缺血和大血管中风亚型. 脑卒中,特别是缺血性脑卒中,也可能增加GERD的风险,这表明双向关系.

科学领域:

遗传学遗传学是一个
流行病学流行病学
胃肠病学胃肠病学

背景情况:

以前的研究表明,胃食道逆流性疾病 (GERD) 和中风之间存在联系.
这种关联的因果性需要进一步调查.

研究的目的:

使用双向门德尔随机化 (MR) 方法探索GERD和中风之间的因果关系.
为了研究中风对GERD的潜在因果作用.

主要方法:

采用了双样双向孟德尔随机化 (MR) 方法.
采用了来自大型全基因组关联研究 (GWAS) 关于中风,其亚型和GERD的总结级数据.
应用了逆方差加权 (IVW) 方法,并进行了质性测试 (MR-Egger,MR-PRESSO,留出一个,Cochran Q).

主要成果:

GERD因果上增加了整体中风的风险 (OR: 1.22,95% CI: 1.13-1.32) 和亚型:缺血性中风 (OR: 1.19),大血管中风 (OR: 1.49) 和缺口性中风 (OR: 1.20).
确定了共同的风险因素,包括2型糖尿病,睡眠呼吸暂停,肥胖和高甘油三.
反向MR分析表明,整体中风 (OR: 1.09) 和缺血性中风 (OR: 1.10) 可能因果性地增加了GERD风险.

结论:

这项MR研究提供了强有力的证据,证明了GERD和中风之间的因果关系.
研究结果表明,这两种情况之间存在双向因果关系.
为了改善预防和治疗策略,需要对潜在机制进行进一步的研究.

关键词:

门德尔的随机化有关因果关系的因果关系胃食道逆流疾病是胃食道逆流疾病.单核酸多形态的单核酸多形态一次性中风中风中风中风中风

更多相关视频

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Surgical Models of Gastroesophageal Reflux with Mice

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

相关概念视频

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...