在视频辅助胸腔镜肺切除术后,术后的斯凯坦胺可以改善通风:双盲随机对照试验
Mengyue Fu1, Rui Xu1, Guizhen Chen1
1Department of Anaesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Heliyon
|February 7, 2024
概括
术后的胺注射与阿片类药物结合,改善了肺透气,并减少了肺切除患者的肺部并发症. 这种疼痛管理策略还降低了氧气不足,改善了患者的康复.
科学领域:
- 麻醉学 麻醉学
- 胸部外科手术 胸部外科手术
- 关键护理医学 关键护理医学
背景情况:
- 肺切除后有效的疼痛管理对于最大限度地减少术后肺部并发症 (PPCs) 至关重要.
- 阿片类止痛药是标准的,但它对通风和PPC的影响需要优化.
研究的目的:
- 为了评估术后斯基坦胺输液作为阿片类药物止痛药的辅助剂的疗效.
- 评估肺切除后患者对通风和肺部并发症的影响.
主要方法:
- 一项随机对照试验,涉及80名接受视频辅助胸腔镜肺切除的患者.
- 一组接受了24小时的sufentanil与esketamine输液;对照组仅接受了sufentanil.
- 主要结果:低分钟通风. 二次结局:低氧化,PPC,住院,疼痛评分 (VAS) 和睡眠质量.
主要成果:
- 乙胺组显著减少了低分钟通风 (P=0.014) 和PPC (P=0.039).
- 低氧化症的发病率较低 (P=0.003),视觉模拟量表 (VAS) 评分和睡眠质量的改善在乙胺组 (P<0.001) 中观察到.
结论:
- 作为阿片类药物止痛药的辅助,术后的石胺注入改善了通风,并减少了肺切除后的PPC.
- 这些发现支持对这种增强疼痛管理方法的进一步临床研究.
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