mtDNA外线粒体复制介导线粒体缺陷效应的影响

Zhaoliang Shan1, Shengnan Li1, Yuxue Gao1

  • 1State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, School of Medicine, Nanjing University, Nanjing 210061, China.

iScience
|February 7, 2024
PubMed
概括

科学家们发现了一种新的途径,涉及Med8/Tfb4-mtSSB/PolG2/mtDNA-helicase,可以挽救中的线粒体缺陷. 这一途径放大了细胞质线粒体DNA,影响疾病和衰老.

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