随着时间的推移,艾滋病毒感染和没有感染的人体质量指数的变化
Jennifer O Lam1, Wendy A Leyden1, Stacey Alexeeff1
1Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Open forum infectious diseases
|February 7, 2024
概括
接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者 (PWH) 经历了显著的体重增加,特别是在治疗的前两年. 这凸显了使用ART监测PWH患者体重和心脏代谢健康的必要性.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 艾滋病毒/艾滋病研究研究
背景情况:
- 过度体重增加是接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者 (PWH) 的重大健康问题.
- 在PWH中,ART对身体质量指数 (BMI) 变化的确切贡献尚不清楚.
研究的目的:
- 调查ART启动与PWH中BMI的纵向变化之间的关联.
- 将PWH在ART中的BMI轨迹与人口统计学上匹配的没有HIV的人 (PWoH) 进行比较.
- 检查不同ART类对BMI变化的影响.
主要方法:
- 一个回顾性研究,将PWH启动ART与PWoH进行比较.
- 分析纵向的BMI数据,使用混合效应模型与片状线性线条进行分析.
- 在统计模型中调整社会人口统计,并发症和物质使用情况.
主要成果:
- 在ART启动后的头两年中,PWH显示平均年BMI增加 (0.53) 与PWoH (0.12) 相比显著更大 (P < .001).
- 在PWH中,在所有ART类 (INSTIs:0.69,PI:0.69,NNRTIs:0.40) 中观察到BMI增加.
- 无论基线BMI如何,BMI与INSTI的增加都发生了,两年后对PWH和PWoH观察到类似的BMI变化.
结论:
- 开始ART的PWH在治疗的最初两年内经历了相当大的体重增加.
- 密切监测体重和心脏代谢健康对于接受ART的PWH至关重要.
- 了解ART对BMI的影响对于管理PWH的长期健康结果至关重要.
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