谷物摄入量和类型与心血管疾病的因果关系:孟德尔的随机化研究
1Department of Cardiology, Ningbo Medical Center of Lihuili Hospital, Ningbo, Zhejiang, China.
Frontiers in nutrition
|February 7, 2024
概括
消费米斯利因果性地降低了心血管疾病 (CVD) 的风险,而饼干和玉米片增加了风险. 这凸显了谷物类型在心血管疾病预防中的重要性,社会经济因素和代谢健康发挥了调解作用.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,谷物消费与心血管疾病 (CVD) 风险降低之间存在联系.
- 谷物摄入量与心血管疾病风险之间的因果关系尚不清楚.
- 调查不同类型的谷物与心血管疾病风险的特定关联至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 确定谷物摄入量和心血管疾病风险之间的因果关系.
- 为了确定特定类型的谷物 (muesli,饼干,玉米片) 对各种心血管疾病结果的影响.
- 探索谷物-心血管疾病协会中的潜在调解因素,包括心血管代谢因素和社会经济地位.
主要方法:
- 使用双步门德尔随机化 (MR) 分析来评估因果关系.
- 用MR-Egger和逆方差加权方法来分析遗传关联.
- 多变量MR分析调查了教育和收入的影响.
- 两步MR分析检查了体重指数,脂质和血糖的调解效应.
主要成果:
- 基因预测的肉摄入量显著降低了冠心病 (CHD),心肌梗塞 (MI),心力衰竭,缺血性中风 (IS),大动脉中风 (LAS) 和小血管中风的风险.
- 基因预测饼干和玉米面的摄入量增加了心脏病,心脏病发作,中风和IS的风险.
- 社会经济因素,如教育和收入,以及代谢因素 (BMI,脂质,葡萄糖),被确定为重要的调解因素.
结论:
- 梅斯利的消费表明对预防心血管疾病有因果有益影响.
- 关于谷物类型的饮食选择显著影响心血管疾病风险.
- 公共卫生建议应考虑特定类型的谷物用于心血管疾病预防策略.
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