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临床结果和瘤微环境对射频废除疗法的反应:系统性审查和元分析

Lauren E Mueller¹, Peter P Issa², Mohammad Hosny Hussein³

¹School of Medicine, Tulane University, New Orleans, Louisiana, USA.

|February 7, 2024

概括

射频切除 (RFA) 是一种癌症治疗方法,但不完全切除可能导致癌症复发. 本综述确定了参与瘤对RFA反应的VEGF和AKT等关键细胞通路,为抵抗机制提供了洞察力.

科学领域:

在瘤学瘤学.
最少侵入性的手术
分子生物学分子生物学

背景情况:

射频切除 (RFA) 是一种使用高能电流摧毁瘤细胞的微创技术.
虽然对各种癌症 (甲状腺,肺,肝脏) 有效,但不完全的切除可以导致瘤复发.
在RFA后的细胞机制和组织行为仍然不太了解.

研究的目的:

系统地审查和分析瘤组织中受RFA影响的细胞机制和信号通路.
确定可能导致RFA耐药性和癌症复发的潜在因素.

主要方法:

在2022年3月之前对EMBASE,科学网络,PubMed和Scopus进行系统审查,并遵守PRISMA指南.
包括人体,体内和体外关于瘤组织的RFA研究,重点关注并发症,复发,存活和细胞信号.
使用Cochrane协作工具和R软件中的统计分析进行偏差风险评估.

主要成果:

肝癌和肺癌是最常被研究的 (分别为57.4%和15.4%).
常见的并发症包括出血 (19%) 和术后疼痛 (14%).
在RFA后升级的关键通路包括VEGF,AKT,矩阵金属蛋白酶和c-Met蛋白.

结论:

几种蛋白质和途径 (VEGF,AKT,MMPs,c-Met) 涉及到伤口愈合,血管生成和RFA后的细胞存活.
这些已识别的途径代表了未来研究RFA耐药性和癌症复发的潜在目标.

关键词:

射频剥离 (RFA) 是一种无线电频率的方法.癌症的复发癌症的复发细胞信号通道的通道.

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