异常的杏仁核子区域功能连接在患有克罗恩氏病的患者中,有或没有焦虑和抑郁症
Jingwen Sun1, Wei Sun1,2, Kecen Yue1,2
1Department of Radiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.
Behavioural neurology
|February 7, 2024
概括
杏仁体的休息状态功能连接 (rsFC) 在克罗恩病 (CD) 患者中发生变化,特别是那些焦虑或抑郁症患者. 这些大脑连接的变化可能会将CD与情绪障碍联系起来.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 克罗恩病 (CD) 是一种慢性炎症性疾病.
- 患有CD的患者经常经历焦虑和抑郁.
- 这些并发症的神经支尚未完全理解.
研究的目的:
- 为了研究杏仁体子区域的静止状态功能连接 (rsFC).
- 为了比较健康对照 (HCs) 中的rsFC与患有CD,有或没有焦虑/抑郁症的患者.
主要方法:
- 使用了功能磁共振成像 (fMRI).
- 对33名患有焦虑/抑郁症的CD患者 (CDad),31名没有焦虑/抑郁症的CD患者 (CDnad) 和29名HC患者进行了rsFC分析.
- 分析了杏仁体子区域与其他大脑区域之间的连接.
主要成果:
- 与HC相比,CDad组显示右侧桃体和左海马/右中额头,左表面桃体和左胰岛之间rsFC减少.
- 与HC相比,CDnad组显示左中枢桃体和左胰岛之间的rsFC减少.
- 与CDnad集团相比,CDad集团在几个地区的rsFC进一步下降.
结论:
- 在CD患者中存在杏仁体亚区域rsFC的显著变化.
- 这些功能连接性变化可能与CD本身或伴随性焦虑和抑郁症有关.
- 杏仁体亚区域的连接模式可以作为CD中心理困扰的生物标志物.
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