引入一种自由呼吸的MRI方法来评估外科手术期间的心肌氧化和功能:一个志愿者队列研究
Dominik P Guensch1, Christoph D Utz, Bernd Jung
1From the Department of Anaesthesiology and Pain Medicine (DPG, CDU, JOF, ST, GE, BE, KF) and Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (DPG, BJ, SD, SPH, ATH).
在麻醉诱导期间的呼吸模式会改变心肌氧化. 持续的自由呼吸氧化敏感心血管磁共振 (OS-CMR) 成像可以量化健康成年人的这些动态变化.
科学领域:
- 心血管生理学心血管生理学
- 医疗成像医学成像
- 麻醉学 麻醉学
背景情况:
- 通用麻醉诱导可以引发外科手术期间的心肌缺血,由于呼吸模式的干扰.
- 氧化敏感心血管磁共振 (OS-CMR) 提供了持续的心肌氧化监测.
研究的目的:
- 评估模拟麻醉诱导呼吸模式对心肌氧化的影响.
- 评估持续的OS-CMR成像,以量化健康成年人的这些影响.
主要方法:
- 一项前性观察性研究,涉及29名健康志愿者.
- 模拟麻醉诱导:节奏呼吸,深呼吸和呼吸暂停 (长达60分钟).
- 采用传统的呼吸暂停OS-CMR和两个自由呼吸的OS-CMR序列 (OS fb-ss,OS fb-rtcine) 获得的心脏图像.
主要成果:
- 在所有成像技术中,模拟麻醉诱导呼吸显著降低了心肌氧氧化率 (P <0.05).
- 随后的呼吸暂停显著增加了心肌氧化 (P < 0.01).
- 自由呼吸的OS-CMR序列显示出可重现性和非劣质性.
结论:
- 模拟麻醉诱导的呼吸动作在年轻成年人中诱导动态的心肌氧化变化.
- 持续自由呼吸的OS-CMR有效量化了这些变化.
- 这些技术可以阐明外科手术期间心肌缺血的机制.
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