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基于凝/聚烯胺的抗菌和自我愈合的水凝膜用于伤口愈合应用

Dimpy Bhardwaj¹, Rakesh Bhaskar², Amit Kumar Sharma^3,4

¹School of Chemical Sciences and Advanced Materials Research Centre, Indian Institute of Technology Mandi, Mandi 175075, Himachal Pradesh, India.

ACS applied bio materials

|February 7, 2024

概括

一种新型的自我愈合的水凝膜,GelAA,被开发用于伤口愈合. 这种无抗生素的膜显示出高吸水率,抗菌性质,并促进细胞增殖,提供了一个有前途的伤口护理解决方案.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
纳米技术纳米技术

背景情况:

先进的伤口包裹对于有效的愈合和预防感染至关重要.
基于水凝的材料为生物医学应用提供了独特的特性,包括药物输送和组织再生.
开发无抗生素的伤口护理解决方案是一个重大未满足的需求.

研究的目的:

合成和表征一种自我愈合,超吸收和粘合性水凝膜 (GelAA).
通过将银纳米集群 (AgNCs) 和ursodeoxycholic acid (UDC) 纳入GelAA膜来开发一种先进的伤口包裹.
评估开发的UDC/Ag/GelAA膜的抗菌活性,多孔性,药物释放动力学和细胞增殖增强.

主要方法:

凝,聚烯胺和酸通过自由基聚合合成了GelAA薄膜.
格尔AA薄膜装载了银纳米集群 (AgNCs) 和ursodeoxycholic acid (UDC),具有10%的装载效率.
描述包括吸水性,自我愈合能力,抗菌检测,毛孔度测量和UDC释放研究.

主要成果:

优化的GelAA薄膜表现出2865±42%的吸水能力和出色的自我愈合特性.
在UDC/Ag/GelAA薄膜中显示出99.99±0.01%的抗菌活性,对抗阳性和阴性细菌.
薄膜呈现出77.19±0.52%的多孔性,并在30小时内释放出90%的UDC,促进细胞增殖.

结论:

建立了一种简单有效的合成多功能水凝膜 (GelAA) 的方法.
开发的UDC/Ag/GelAA薄膜由于其结合性质,显示出作为无抗生素伤口愈合剂的巨大潜力.
这项研究为先进的伤口护理应用提供了一个有前途的平台,解决感染并促进组织再生.

关键词:

抗微生物药物是一种抗菌药物.药物释放释放药物释放药物释放的时间它具有自我愈合的功能.银纳米集群中的银纳米集群.伤口愈合伤口愈合

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