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种族特定的关联:炎症调解剂和慢性腰部疼痛

Demario S Overstreet^1,2,3, Larissa J Strath^4,5,6, Robert E Sorge⁷

¹Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Woman's Hospital, Boston, MA, United States.

|February 7, 2024

概括

黑人和白人之间的慢性腰部疼痛 (cLBP) 差异可能源于不同的炎症标志物. 了解这些生物差异对于有针对性的治疗和减少健康不平等至关重要.

科学领域:

生物医学科学生物医学科学
疼痛研究疼痛研究
健康差异在健康上的差异

背景情况:

慢性腰部疼痛 (cLBP) 是一个重要的全球健康问题.
与非西班牙裔白人 (NHW) 个人相比,非西班牙裔黑人 (NHB) 个人经历了不成比例的cLBP负担.
在cLBP中驱动这些种族差异的生物机制尚不清楚.

研究的目的:

调查与疼痛干扰,休息疼痛和运动引起的疼痛相关的炎症调解者是否根据cLBP患者的种族身份而有所不同.
在NHB和NHW人群中确定与cLBP结果相关的特定炎症生物标志物.

主要方法:

从156名cLBP (98名NHB,58名NHW) 个体收集了血液样本.
与酶相关的免疫吸收试验和多重试验量化了促炎 (纤维素,CRP,血清粉样蛋白A,TNF-α,IL-1α,IL-1β,IL-6) 和抗炎 (IL-4,IL-13) 标志物.
斯皮尔曼相关性评估了炎症标志物和疼痛结果之间的关联,使用简要的疼痛清单-简短表格.

主要成果:

在NHW患者中,CRP,血清粉样蛋白A和IL-6与cLBP结果具有积极的关联,而IL-4与静止疼痛和运动引起的疼痛相反相关.
在NHB患者中,只有IL-1α显示出与静止疼痛的积极关联.
这些发现表明,在不同种族群体中,与cLBP相关的不同炎症概况.

结论:

炎症与cLBP结局有关,但特定的潜在生物标志物在种族群体之间可能有很大差异.
在cLBP的种族差异可能受到与炎症相关的独特生物机制的影响.
需要对多样化和包容性样本进行进一步的研究,以充分理解和解决导致cLBP种族差异的机制.

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