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在关键手术疾病中,通过非编码RNA进行肠粘膜生长和适应的转录后调节
Cassandra A Cairns1, Lan Xiao1, Jian-Ying Wang1,2,3
1Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland21201, USA.
概括
非编码RNAs (ncRNAs) 是肠道上皮质平衡的关键调节者. 了解它们在损伤和修复中的作用,为手术患者的肠道完整性提供了新的治疗目标.
科学领域:
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
- 手术病理生理学 手术病理生理学
背景情况:
- 肠上皮维持稳态,但在重症手术患者中容易受到急性损伤.
- 这种损伤可能导致肠道屏障功能障碍,粘膜出血和细菌转移,治疗选择有限.
- 对粘膜干扰背后的机制的不充分理解,阻碍了有效的治疗开发.
研究的目的:
- 审查非编码RNAs (ncRNAs) 在肠上皮质平衡,损伤和修复中的作用.
- 突出ncRNAs在肠道外科手术术后的术后恢复中的重要性.
- 探索ncRNAs作为保护肠道完整性的潜在治疗点.
主要方法:
- 文献综述侧重于非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长ncRNAs (lncRNAs),圆形RNAs (circRNAs) 和小密室RNAs (vtRNAs).
- 分析肠道表皮中的lncRNAs,miRNAs和RNA结合蛋白之间的相互作用.
- 检查ncRNA对细胞存活,增殖,迁移和细胞间相互作用的影响.
主要成果:
- ncRNAs是肠上皮质平衡,粘膜生长,屏障功能和修复的关键编排者.
- lncRNAs,miRNAs和RNA结合蛋白之间的相互作用显著影响肠道上皮细胞功能.
- 特定的ncRNA在肠道外科手术术后的术后恢复过程中发挥着至关重要的作用.
结论:
- ncRNAs对于保持肠道上皮质完整性和功能至关重要.
- 对ncRNA生物学的先进理解揭示了它们对关键外科疾病的治疗潜力.
- 对于旨在保护肠道表皮的治疗方法,ncRNAs代表了有希望的新目标.
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