患有肠道衰竭的儿童的状况
Heitor Pons Leite1,2, Eduardo Freitas Hatanaka1,2, Giovana Sertori Galati Sabio1
1Center for Intestinal Rehabilitation, Transplant Division, Hospital Samaritano de São Paulo, São Paulo, Brazil.
Journal of pediatric gastroenterology and nutrition
|February 7, 2024
概括
长期接受管营养 (PN) 的儿童经常出现缺乏症 (ID). 从营养配方中增加的摄入量可以改善状态,并减少儿科肠衰竭 (IF) 患者的ID患病率.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 需要长期的肠外营养 (PN) 的儿童容易患缺乏症 (ID).
- 这一群体中关于ID的现有数据主要来自横截面研究.
- 需要纵向数据来了解患有肠衰竭 (IF) 的儿童的状况和相关因素.
研究的目的:
- 调查长期接受PN的IF儿童的状况.
- 为了确定与状况相关的因素.
- 为了确定这个队列中甲状腺功能低下症的患病率.
主要方法:
- 一项队列研究跟踪了接受肠道康复的FI儿童.
- 关键的监测参数包括尿液度 (UIC),摄入量,水平和甲状腺功能.
- ID被定义为UIC<100μg/L;统计分析使用了概括的估计方程.
主要成果:
- 分析了24名儿童 (平均年龄为62.7个月) 的PN,平均时间为46.5个月.
- 智障患病率从基线的83.3%下降到最终评估时的45.8%.
- 从营养配方中摄入和UIC (β = 0.71; p < 0.001) 之间发现了正相关性.
结论:
- 缺乏症在长期PN的IF儿童中很常见,但其患病率随着营养配方中充足的摄入量而降低.
- 严重的和缺乏与这些儿童的甲状腺功能低下症发展有关.
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