使用认知措施预测阿尔茨海默病痴呆症的进展
Amy Macdougall1, Tim Whitfield2, Kelly Needham3
1Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
International journal of geriatric psychiatry
|February 7, 2024
概括
全球功能,记忆和精神运动速度等认知测试有效地预测阿尔茨海默病 (AD) 痴呆症在记忆诊所. 随着时间的推移跟踪认知变化进一步提高了AD痴呆症的预测准确性.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 老年病的医生 老年病的医生
背景情况:
- 认知措施在痴呆症研究中的预后可能在记忆诊所具有临床实用性.
- 确定预测性认知措施对于早期阿尔茨海默病 (AD) 痴呆症检测至关重要,特别是当生物标志物不可用时.
研究的目的:
- 在记忆诊所环境中,确定具有对未来阿尔茨海默病 (AD) 痴呆症预测能力最高的认知措施.
- 在现实临床环境中评估认知测量对预测AD痴呆症进展的有用性.
主要方法:
- 利用了18年的日常记忆诊所数据,来自328名患有主观认知衰退或轻度认知障碍的患者.
- 使用基线认知测试得分的统计模型与包括基线和1年随访认知变化得分的模型进行了比较.
- 对转化为阿尔茨海默病 (AD) 痴呆症的评估预测.
主要成果:
- 全球认知功能的基线分数 (迷你心理状态检查,剑桥认知检查修订),口头情节性记忆和精神运动速度是AD痴呆症最强的预测因素.
- 包括1年随访的认知变化得分,与单独的基线得分相比,AD痴呆症预测的准确性显著提高.
- 在临床环境中最有效的认知预测指标与研究队伍中识别的认知预测指标一致.
结论:
- 在研究队伍中有效的认知措施在记忆诊所设置中也很有价值,用于预测阿尔茨海默病 (AD) 痴呆症.
- 随着时间的推移,纳入认知功能的变化可以提高预测AD痴呆症发病的准确性.
- 记忆诊所的常规认知评估可以帮助早期识别患有AD痴呆症风险的个体.
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