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Updated: Jul 4, 2025

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
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对腺病毒C5 hexon和人类乳酸铁素之间的相互作用的结构洞察

Arun Dhillon1, B David Persson2, Alexander N Volkov3,4

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.

Journal of virology
|February 7, 2024
PubMed
概括

人类乳酸 (hLF) 通过与病毒子蛋白结合,有助于腺病毒进入呼吸道细胞. 这种由冷-EM结构详述的相互作用揭示了病毒吸收的新途径,这对于基因疗法和疫苗开发至关重要.

关键词:
腺病毒的病毒.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.免疫逃避 免疫逃避乳酸铁氨酸 (lactoferrin) 是一种乳酸铁氨酸.病毒入口病毒入口.

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