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使用双能圆束计算断层扫描检测骨髓的可行性

Stephen Z Liu¹, Magdalena Herbst², Jamin Schaefer²

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Medical physics

|February 7, 2024

概括

双能量 (DE) 圆束计算断层扫描 (CBCT) 现在可以使用先进的工件校正和材料分解检测骨髓胀 (BME). 这种技术在临床环境中对定量骨健康评估具有前景.

科学领域:

医疗成像医学成像
整形外科整形外科整形外科
放射学放射学是一门学科.

背景情况:

检测骨髓 (BME) 的双能量 (DE) 检测是骨科圆束计算断层扫描 (CBCT) 的一个有价值的能力.
由于水和脂肪之间的能量分离很窄,精确的BME检测具有挑战性,需要精确的工件校正和材料分解.

研究的目的:

研究使用kV切换DE CBCT进行BME评估的可行性.
采用全面的CBCT文物校正框架和BME检测的两阶段分解算法.

主要方法:

从BME幽灵和动物尸体模型中获得的DE CBCT数据,使用kV切换协议 (60 kV LE,120 kV HE).
实施了预处理和文物校正框架,包括投影插曲,滞后/光解卷和基于蒙特卡洛 (MC) 的散射校正.
通过投影和图像域分解生成虚拟非 (VNCa) 图像,将其分解成水,和脂肪,以检测BME.

主要成果:

基于MC的散射校正减少了超过69%的缩器件,用于更广泛的合并,从而实现了精确的DE材料分解.
在前臂大小的物体中,水度 () 增加了20%被可视化为~15 HU VNC,与此相反.
接收器操作特征 (ROC) 曲线显示曲线下面的面积大于0.9;MRI确认的尸体样本中的BME与VNCa增强相对应.

结论:

拟议的文物校正和材料分解管道有效地解决了在DE CBCT中准确检测BME的散射和光谱分离挑战.
这项研究为DE CBCT的临床翻译建立了基线,用于定量,关怀点骨健康评估.

关键词:

蒙特卡洛模拟的蒙特卡洛模拟伪造的纠正伪造的纠正骨髓胀骨髓胀骨髓胀圆光束CT CT 的情况.双能量CT是双能量CT.多种材料的分解分解.肌肉骨成像系统成像

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