高血压患者的风险因素控制程度和心血管疾病发生率
Minghao Kou1, Xuan Wang1, Hao Ma1
1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
Mayo Clinic proceedings
|February 7, 2024
概括
控制多种风险因素可显著降低高血压患者心血管疾病 (CVD) 风险. 实现最佳控制可以消除与高血压相关的过度心血管疾病风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 预防医学 预防医学
背景情况:
- 高血压显著增加了心血管疾病 (CVD) 的风险.
- 管理多种风险因素对于心血管健康至关重要.
研究的目的:
- 确定多种风险因素的联合控制是否能降低高血压患者心血管疾病风险的增加.
- 评估综合风险因素管理对心血管疾病结果的影响.
主要方法:
- 利用了来自75,293名高血压患者和256,619名对照组的英国生物库数据.
- 评估了七个危险因素:血压,BMI,LDL胆固醇,HbA1c,白蛋白尿,吸烟和体育活动.
- 用Cox的比例危险模型来分析结果.
主要成果:
- 每一个额外的受控风险因素都将心血管疾病风险降低了14%至24%.
- 具有6+控制因素的患者心血管疾病 (HR 0.49),冠心病 (HR 0.51),中风 (HR 0.48) 和心血管疾病死亡率 (HR 0.34) 的风险显著降低.
- 与对照组相比,高水平的风险因素控制消除或逆转了高血压患者心血管疾病风险的过剩.
结论:
- 联合风险因素控制与降低心血管疾病风险密切相关.
- 对多种风险因素的积极管理可以大大减轻高血压中心血管疾病风险的增加.
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