发性心肌炎暂时与COVID-19疫苗接种有关
Enrico Ammirati1,2, Nicolina Conti3, Matteo Palazzini3
1De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Transplant Center, Milan, Italy. enrico.ammirati@ospedaleniguarda.it.
Current cardiology reports
|February 7, 2024
概括
接种COVID-19疫苗后发生的 fulminant心肌炎 (FM) 的罕见病例与非 fulminant 形式不同,死亡率高. 了解这些严重的疫苗副作用对于公共卫生至关重要.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 冠状病毒疾病-2019 (COVID-19) 疫苗与罕见的急性心肌炎病例有关.
- 虽然大多数病例是轻微的,但有一小部分患有 fulminant心肌炎 (FM),这是一种严重的形式,带有心脏性休克.
研究的目的:
- 探索COVID-19疫苗相关急性心肌炎的流行,临床表现,管理和预后.
- 特别关注发性心肌炎 (FM),并与非发性病例进行比较.
主要方法:
- 在2023年2月之前,在COVID-19疫苗接种后30天内检查了40例FM病例.
- 与现有文献中294例非发性急性心肌炎病例进行比较.
- 临床特征,成像和组织学发现的分析.
主要成果:
- 全发性心肌炎 (FM) 占疫苗相关心肌炎病例的2-4%,在本综述中报告的死亡率为27%.
- 患有FM的患者年龄较大,女性比例较高,与非发病病例相比,在第一剂疫苗接种后发生的病例更频繁.
- 临床和组织学发现表明疫苗相关的FM有不同的机制.
结论:
- 与COVID-19疫苗相关的FM与非发性形式呈现不同,这表明了独特的潜在机制.
- 疫苗相关的FM的死亡率仍然很高,与非疫苗相关的FM相比.
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