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Updated: Jul 4, 2025

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Smurf1调节纤维性白内障形成中的Smad信号通路

Fanying Jiang1, Yuanfan Yang1, Yan Ni1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Investigative ophthalmology & visual science
|February 7, 2024
PubMed
概括

Smurf1是纤维性白内障的关键调节剂,促进了透镜上皮细胞的增殖,迁移和EMT. 抑制Smurf1为纤维性白内障提供了一个潜在的治疗策略.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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