性别特定的途径从产前母亲的炎症到青少年的抑郁症状
Emily Lipner1, Naoise Mac Giollabhui1,2, Elizabeth C Breen3
1Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania.
JAMA psychiatry
|February 7, 2024
概括
产前母亲的炎症与后代的青少年抑郁症有关. 具体的炎症标志物和怀孕期间的时间,以及后代的性别和童年症状,影响这些关联.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展生物学 发展生物学
背景情况:
- 产前母亲炎症与成人抑郁症和后代的儿童行为症状有关.
- 产前炎症和青少年抑郁症之间的关联仍未得到充分研究.
研究的目的:
- 调查怀孕期间母亲炎症生物标志物与青少年后代抑郁症状之间的关联.
- 探索妊娠时间,后代的性别和儿童精神症状如何改变这些关联.
主要方法:
- 使用基于人口的出生队列 (儿童健康和发展研究) 的观察性研究.
- 测量母亲血清炎症生物标志物 (IL-6,IL-8,IL-1RA,sTNF-RII) 在第一和第二个三个月.
- 在青春期 (15-17岁) 评估了后代的抑郁症状,并收集了儿童时期 (9-11岁) 的数据.
主要成果:
- 第二个三个月的高interleukin-6 (IL-6) 与青少年抑郁症状的增加有关.
- 儿童时期外化症状调解了第一季度IL-6和男性抑郁症之间的联系.
- 儿童内化症状调解了第二季度IL-1受体对手 (IL-1RA) 与女性抑郁症之间的联系.
结论:
- 产前母亲炎症与青少年后代的抑郁症状有关.
- 将产前炎症与青少年抑郁症联系在一起的途径因妊娠时间和后代性别而异.
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