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Updated: Jul 4, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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在体外通过其替代拼接异型对α-synuclein的聚合动力学进行调节

Alexander Röntgen1, Zenon Toprakcioglu1, James E Tomkins1,2

  • 1Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|February 7, 2024
PubMed
概括

阿尔法-同核素 (αSyn) 的替代拼接产生比标准形式更快聚合的异构体. 这种αSyn-112和αSyn-98的加速聚合可能有助于帕金森病的发病.

关键词:
这是一种α-synuclein.蛋白质形式的蛋白质形式拼接的异形形式.

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