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Updated: May 2, 2026

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来自HL-60细胞系的中性粒细胞样细胞作为中性粒细胞脱粒化的遗传可追溯模型

Suhani B Bhakta1, Stefan M Lundgren2, Bethany N Sesti1

  • 1Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.

PloS one
|February 7, 2024
PubMed
概括

来自HL-60和PLB-985细胞系的中性粒细胞类细胞 (NLC) 有效地模拟中性粒细胞脱粒,释放各种分泌器官. 补充Nutridoma并没有在HL-60衍生的NLC中增强这种功能.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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