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来自立陶宛的传播脑炎病毒的家族遗传特征

Marina Sidorenko¹, Jana Radzijevskaja¹, Saulius Mickevičius¹

¹Department of Biology, Faculty of Natural Sciences, Vytautas Magnus University, Kaunas, Lithuania.

|February 7, 2024

概括

立陶宛的性脑炎病毒 (TBEV) 菌株是该地区特有的,属于欧洲亚型. 分析显示,菌株之间存在显著的遗传多样性,变异与地理位置有关,而不是物种.

科学领域:

病毒学病毒学
流行病学流行病学
遗传学遗传学是一个

背景情况:

波罗的海国家,特别是立陶宛,对传播脑炎 (TBE) 的流行率很高.
自1992年以来,立陶宛的TBE发病率大幅上升.
之前的研究证实了TBE病毒 (TBEV) 在局部的流行率,并确定了特有病源.

研究的目的:

进行在立陶宛流传的TBEV菌株的分子表征和植物遗传分析.
基于部分E蛋白和NS3基因序列的TBEV基因型,来自立陶宛的虫隔离物.

主要方法:

从Ixodes ricinus和Dermacentor reticulatus获得的54个TBEV分离物的部分E蛋白和NS3基因的测序.
遗传学分析比较立陶宛TBEV序列与NCBI数据库中的81个菌株.

主要成果:

所有34个分析的立陶宛TBEV分离物都属于欧洲亚型,显示出该地区的特异性.
与Neudoerfl参考菌株的最大一致性为98.7% (E基因) 和97.4% (NS3基因).
观察到显著的区域遗传多样性,遗传差异与地理位置相关,而不是物种.

结论:

立陶宛TBEV菌株在遗传上是不同的,在欧洲亚型中形成一个特定的集群.
地理位置是立陶宛TBEV遗传多样性的关键因素.
了解这种遗传多样性对于特有地区的TBEV监测和控制至关重要.

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