空间对比的变化自编码器用于从空间解析的转录组学解读组织异质性

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Yaofeng Hu1, Kai Xiao2,3, Hengyu Yang1

  • 1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou 310024; University of Chinese Academy of Sciences, China.

Briefings in bioinformatics
|February 7, 2024
PubMed
概括

我们开发了Spatially Contrastive变化自编码器 (SpaCAE),这是一个空间转录组学 (SRT) 的新框架. SpaCAE准确地检测空间功能区域,并通过在组织微环境中对比基因表达信号来提高数据质量.

关键词:
图形嵌入式变化自动编码器空间域识别空间域识别空间对比的学习学习空间分辨率的转录学

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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