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Updated: Jul 4, 2025

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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DRAK2通过在Ser56中酸化ULK1来抑制自,从而在过度营养时降低胰腺β细胞功能

Yuting Lu1, Junyu Xu1,2, Yufeng Li1

  • 1State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai, 201203, P. R. China.

Science translational medicine
|February 7, 2024
PubMed
概括

与DAP相关的亡诱导激酶-2 (DRAK2) 在2型糖尿病中被上调,损害胰腺β细胞功能. 抑制DRAK2通过维持自和线粒体功能来保护β细胞,提供潜在的治疗点.

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