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相关概念视频

Allergic Reactions02:06

Allergic Reactions

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Overview
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Antibody Structure01:10

Antibody Structure

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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相关实验视频

Updated: Jul 4, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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过敏中的IgE:需要两个.

Anouk von Borstel1, Robyn E O'Hehir1,2, Menno C van Zelm1,2,3

  • 1Department of Immunology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.

Science translational medicine
|February 7, 2024
PubMed
概括

一种特定类型的记忆B细胞被原始化,在过敏患者中产生IgE抗体. 这一发现促进了对过敏疾病机制的理解.

科学领域:

  • 免疫学 免疫学 免疫学
  • 过敏研究 研究过敏
  • 细胞生物学 细胞生物学

背景情况:

  • 过敏包括免疫球蛋白E (IgE) 抗体的产生.
  • B细胞是适应性免疫反应的关键参与者.
  • 记忆B细胞提供长期免疫力,但可以参与过敏反应.

研究的目的:

  • 为了确定参与过敏个体IgE生产的特定B细胞子集.
  • 了解导致过敏的B细胞的分化途径.

主要方法:

  • 对B细胞群体的流细胞计分析.
  • 记忆B细胞的免疫表型.
  • 在IgE分泌细胞的分化潜力的评估.

主要成果:

  • 鉴定出了2型B型记忆细胞的一个独特子集.
  • 这一子群显示出分化为产生IgE的血细胞的倾向.
  • 这些发现是在被诊断患有过敏的人群中观察到的.

结论:

  • 2型B型记忆细胞代表了在过敏中产生IgE的关键细胞来源.

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  • 针对这种B细胞子集可能为过敏性疾病提供新的治疗策略.