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Updated: Jul 4, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

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MutSβ-MutLβ-FANCJ轴介导在配转录G4/R循环中分叉停滞后重启DNA复制

Esin Isik1, Kaustubh Shukla2, Michaela Pospisilova3,4

  • 1Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Science advances
|February 7, 2024
PubMed
概括

DNA复制分叉在转录复制冲突 (TRC) 中停滞,形成G-四重复/R-循环. MutSβ,MutLβ和FANCJ解决了这些结构,使复制重启.

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