大脑白质负担与接受血液透析的患者的认知功能有关
Tsai-Shan Wu1, Ping-Hsun Wu2,3,4, Hsiu-Fen Lin5
1Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Annals of medicine
|February 7, 2024
概括
慢性病患者接受血液透析显示认知能力下降与白质变化相关. 周心室白质超强度 (PVWMHs) 与认知测试的表现差显著相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 慢性病 (CKD) 与神经退行和认知障碍有关.
- 白质过强度 (WMHs),通过Fazekas尺度进行评估,与认知能力下降有关.
研究的目的:
- 为了研究法泽卡斯尺度得分和血液透析患者的认知功能之间的关联.
- 通过使用MMSE,MoCA和CASI对WMHs进行认知表现的评估.
主要方法:
- 59名血液透析患者接受了脑部MRI,使用Fazekas尺度对周周结节 (PV) 和深度 (DWMHs) WMH进行分级.
- 认知功能使用迷你心理状态检查 (MMSE),蒙特利尔认知评估 (MoCA) 和认知能力查仪器 (CASI) 进行评估.
- 多变量回归模型确定了认知得分和Fazekas尺度分级之间的关联.
主要成果:
- 在认知测试 (MMSE,MoCA,CASI) 和PVWMH (p < .05) 之间发现了不良关联.
- 对于深层WMH (DWMHs),关联较弱.
- PVWMHs显著影响了CASI子域,包括记忆,语言和流性;DWMHs影响了抽象思维和短期记忆.
结论:
- 周心室白质超强度与血液透析患者的认知功能相反相关.
- 包括记忆和语言在内的认知表现与这一群体中的PVWMH有显著的关联.
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