新生儿发作的神经发育结果:一项纵向研究
Licia Lugli1, Maria Carolina Bariola1, Isotta Guidotti1
1Neonatology Unit, Mother-Child Department, University Hospital of Modena, Italy.
概括
新生儿发作 (NS) 是常见的,缺氧缺血性脑病是最常见的原因. 新生儿发作的和状态与婴儿神经发育结果的恶化有关.
科学领域:
- 新生儿神经学 新生儿神经学
- 儿科是儿童的.
- 神经发育障碍 神经发育障碍
背景情况:
- 新生儿发作 (NS) 是新生儿的一个关键的神经紧急情况.
- 国际抗联盟 (ILAE) 的分类将发作半学与病因联系起来,但神经发育结果需要进一步评估.
- 了解NS病因和发作特征对于预测长期结果至关重要.
研究的目的:
- 评估发作的新生儿的神经发育结果.
- 确定与NS中严重神经发育结果相关的风险因素.
- 为了与长期预后相关联的半学和病因学.
主要方法:
- 通过视频脑电图 (EEG) 对74名新生儿的评估证实了NS.
- 分析发作病因,脑MRI,背景EEG,一般运动和神经发育评估.
- 严重结局的定义包括死亡,脑,发育迟缓,,聋或失明.
主要成果:
- 低毒性缺血性脑病变是急性引起的NS的主要病因 (83.8%).
- 新生儿发作的 (16.2%) 与急性引起的NS相比,预后更差.
- 严重的结局 (44.6%) 与新生儿发作的,状态和异常的一般运动有关.
结论:
- 缺氧缺血性脑病变仍然是NS的主要原因.
- 新生儿发作的预后比急性引起的NS更差.
- 状态是新生儿发作中不良神经发育结果的重要预测因素.
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