在口腔和喉癌中,酒精消耗和10年死亡率
Shihoko Koyama1, Takahiro Tabuchi1, Toshitaka Morishima1
1Cancer Control Center, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, Osaka 541-8567, Japan.
Cancer epidemiology
|February 7, 2024
概括
过度饮酒会增加口腔和喉癌患者的死亡风险. 这项研究发现,与不饮酒者相比,大量饮酒者死亡风险更高,影响男性和女性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于酒精对口腔和喉癌患者预后的影响的数据有限且相互矛盾.
- 以前主要来自欧洲的研究主要集中在更短的生存期 (长达5年).
研究的目的:
- 研究日本口腔和喉癌患者的酒精消费与10年死亡率之间的关联.
- 提供对酒精对该患者队列生存的长期影响的全面分析.
主要方法:
- 日本一家医院癌症登记处在1975年至2010年间诊断出2626名癌症患者.
- 患者的随访时间长达10年,饮酒量分为五个级别 (非饮酒者,前饮酒者,轻度,中度,重度).
- 考克斯比例危险回归被用来分析10年全因死亡率,调整各种临床和人口因素.
主要成果:
- 与非饮酒者相比,前饮酒者和重饮者死亡风险明显高 (HR=1.59和HR=1.36).
- 过度饮酒与男性 (HR=1.35) 和女性 (HR=2.52) 的死亡率增加有关.
结论:
- 大量的酒精消费 (每天超过46克) 与口腔和喉癌患者的死亡风险增加有关.
- 沉重饮酒与增加死亡率之间的这种联系在两种性别中都是一致的.
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