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根据全基因组关联研究的基础上,母猪过度繁殖和 litter 尺寸优化的遗传基础

Błażej Nowak¹, Anna Mucha¹, Magdalena Zatoń-Dobrowolska¹

¹Department of Genetics, Wrocław University of Environmental and Life Sciences, Kożuchowska 7, 51-631, Wrocław, Poland.

|February 7, 2024

概括

全基因组关联研究发现了七号染色体上显著的SNP影响母猪的过多生殖能力. 这一发现有助于了解猪中大 litter 尺寸的遗传基础,这对于提高生殖效率至关重要.

科学领域:

动物遗传学动物遗传学
生殖生物学生殖生物学
基因组学就是基因组学.

背景情况:

增加母猪子大小带来了诸如延长分娩时间和降低小猪活力等挑战.
母猪生育率的进一步增加可能会导致管理低出生体重的子的困难和成本.

研究的目的:

通过全基因组关联研究 (GWAS) 调查母猪过度繁殖的遗传基础.
为了确定与母猪过大 litter 尺寸相关的特定遗传标记.

主要方法:

使用PorcineSNP60v2BeadChip微阵列 (64,232个SNP) 来对144头母猪进行基因型鉴定.
包括质量控制和GWAS在内的统计分析,使用五种物流回归模型.
较量母猪的最佳子大小 (14-16小猪) 与过度子大小 (>16小猪) 的母猪.

主要成果:

一个显著的单核酸多态 (SNP),SIRI0000069,在EFCAB11基因中的染色体7上被识别出来,与母猪的过度繁殖性密切相关.
另外10个SNP显示出与 litter 尺寸几乎显著的关联 (p < 1e-5).
这些显著和近显著的SNP位于已知的染色体上,用于生殖特征的定量特征位点 (QTLs).

结论:

染色体7上的EFCAB11基因区域是一个关键的遗传区域,影响母猪的繁殖能力.
GWAS是一种有效的工具,用于剖析猪复杂生殖特征的遗传结构.
识别这些遗传标记可以为养殖策略提供信息,以管理子大小并提高小猪的生存能力.

关键词:

在GWAS中,GWAS就是GWAS.过度生育的母猪是多产的垃圾大小垃圾大小垃圾大小猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪在SNP中,SNP是SNP.

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