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Updated: Jul 4, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

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基于2.2'-(pyridin-2-ylmethylene) bis(5,5-dimethylcyclohexane-1,3-dione) 的复合物及其DNA,BSA结合倾向和DFT研究的抗癌行为

Mohamed A Ragheb1, Marwa H Soliman1, Ismail A Abdelhamid2

  • 1Department of Chemistry (Biochemistry Division), Faculty of Science, Cairo University, Giza, Egypt.

Journal of inorganic biochemistry
|February 7, 2024
PubMed
概括

一种新型的复合体通过诱导细胞亡和细胞循环停止,对结肠癌细胞表现出显著的抗癌活性. 这种有前途的化合物还表现出抗菌性质和与DNA和蛋白质的良好相互作用.

关键词:
它具有抗癌性活性.抗微生物特征 抗微生物特征细胞灭亡 (apoptosis) 是一种死亡的过程.结合DNA/BSA的结合方式Pd (二) 复杂的复杂的在S-阶段.

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