在SARS-CoV-2肺栓塞后的慢性血栓栓塞性肺高血压
Oswaldo Antonio Caguana-Vélez1,2,3, Karys Khilzi4,5, Lucilla Piccari4,5
1Respiratory Medicine Department, Hospital del Mar, Barcelona, Spain, oswaldoantonio.caguana01@estudiant.upf.edu.
Respiration; international review of thoracic diseases
|February 7, 2024
概括
在COVID-19相关的肺栓塞 (PE) 后持续的肺血管缺陷影响了18%的患者. 慢性血栓栓塞性肺病 (CTEPD) 发病率在2年内为0.75%,低于非COVIDPE.
科学领域:
- 肺部医学 肺部医学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 慢性血栓栓塞性肺病 (CTEPD) 涉及到持续的血管阻塞和功能限制.
- 在COVID-19期间的肺栓塞 (PE) 可能导致长期并发症.
- 了解COVID后的PE后续症状对于患者管理至关重要.
研究的目的:
- 评估COVID-19相关PE后持续性肺血管缺陷和CTEPH的发生率.
- 在2年的随访期间,确定这些长期并发症的危险因素.
主要方法:
- 对133名住院患有COVID-19和PE的患者进行前性观察性研究.
- 随访包括成像 (CTPA/scintigraphy),肺功能测试和心声回声.
- 对残留的血栓性缺陷的评估发生在出院后3-4个月.
主要成果:
- 18%的患者在成像上表现出持续的血栓性缺陷.
- 在两年内,CTEPD的发病率为0.75%.
- 高龄,高血压,较高的D-二次数/NT-proBNP和诊断时的右心室功能障碍与缺陷有关.
结论:
- 在COVID-19相关的PE后,持久性血栓缺陷很常见.
- 在这个队列中,CTEPH的发病率低于非COVID PE.
- 在PE诊断时的右心室功能障碍独立预测了持续的缺陷.
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